|Year : 2015 | Volume
| Issue : 4 | Page : 223-226
Multiple hemorrhages in brain after spine surgery supra- and infra-tentorial components together
Baran Yilmaz1, Semra Isik2, Murat Sakir Eksi3, Emel Ece Özcan Eksi3, Akin Akakin1, Zafer Orkun Toktas1, Deniz Konya1
1 Department of Neurosurgery, Medical School, Bahçeşehir University, Istanbul, Turkey
2 Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey
3 Department of Orthopaedic Surgery, Spine Center, University of California at San Francisco, CA, USA
|Date of Web Publication||21-Oct-2015|
Dr. Murat Sakir Eksi
Department of Orthopaedic Surgery, University of California at San Francisco, 500 Parnassus Avenue, MU 320 West, San Francisco, CA 94143-0728
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Remote cerebellar hemorrhage after cranial and spinal surgeries is a well-documented entity, so far concomitant supra- and infra-tentorial hemorrhage after spine surgery has rarely been reported in the literature. A 57-year-old woman presented with intractable low back pain and severely impaired mobility. One year ago, she underwent lumbar laminectomy and fusion with posterior spinal instrumentation between L2 and S1. She developed adjacent segment disease at the upper level of the instrumented vertebra. She had a revision surgery and underwent posterior laminectomy and fusion with bilateral transpedicular instrumentation between T10 and S1. She had severe headache, somnolence, and left hemiparesia 48 h after the surgery. Her emergent head computed tomography depicted intra-parenchymal hemorrhage in the right parietal lobe accompanying with subarachnoid hemorrhage, bilateral symmetrical cerebellar hemorrhages and pneumocephalus. She was treated nonsurgically and she got better despite some residual deficits. Symptoms including constant headache, nausea, vomiting, impaired consciousness, new onset seizure, and focal neurological deficit after spine surgeries should raise suspicion for intracranial intra-parenchymal hemorrhage.
Keywords: Cerebrospinal fluid, intracranial hemorrhage, spine, surgery
|How to cite this article:|
Yilmaz B, Isik S, Eksi MS, Eksi EÖ, Akakin A, Toktas ZO, Konya D. Multiple hemorrhages in brain after spine surgery supra- and infra-tentorial components together. J Craniovert Jun Spine 2015;6:223-6
|How to cite this URL:|
Yilmaz B, Isik S, Eksi MS, Eksi EÖ, Akakin A, Toktas ZO, Konya D. Multiple hemorrhages in brain after spine surgery supra- and infra-tentorial components together. J Craniovert Jun Spine [serial online] 2015 [cited 2020 Jun 2];6:223-6. Available from: http://www.jcvjs.com/text.asp?2015/6/4/223/167890
| Introduction|| |
Postoperative remote intracranial hemorrhage has the same risk factors as nontraumatic intracranial bleeding: Hypertension, coagulopathy, anticoagulant therapy, and vascular disorders.  Remote intracranial hemorrhage, particularly cerebellar hemorrhage after spine surgery, has been well-documented in the literature. ,,,, However, concomitant supra- and infra-tentorial intra-parenchymal hemorrhage after spine surgery is very rare, since 7 cases were reported in the literature. ,,,,,,
We present a 57-year-old female with intracranial multiple hemorrhages after spine surgery and we discuss diagnosis, patho-mechanism, and treatment approaches with a review of the relevant data in the literature.
| Case Report|| |
A 57-year-old female presented with intractable low back pain and severely impaired mobility. One year ago, she underwent lumbar laminectomy and fusion with posterior spinal instrumentation between L2 and S1. Her motor strength was 4/5 in her lower limbs, and she had decreased sensation in bilateral dermatomes from L1 to S1. She developed adjacent segment disease at the upper level of the instrumented vertebra [Figure 1]a. Then, she had a revision surgery of posterior laminectomies (T11-L1) and posterior spinal fusion with bilateral transpedicular instrumentation from T10 to S1 [Figure 1]b. A hemovac drain was placed into the epidural space.
|Figure 1: Adjacent segment disease is observed at the proximal junction of the instrumentation (a). Lateral spinal X-ray after revision surgery (b)|
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Postoperative neurological examination and laboratory values were within normal limits. However, she had severe headache, somnolence, and left hemiparesia 48 h after the surgery. Her emergent head computed tomography revealed intraprenchymal hemorrhage in the right parietal lobe accompanying with subarachnoid hemorrhage, bilateral symmetrical cerebellar hemorrhages and pneumocephalus [Figure 2]. The hemovac drain was removed and the drain exit site was closed with a single suture. The patient was admitted to Intensive Care Unit and managed nonsurgically. She received both antiedema (4 mg dexamethasone intravenous [I.V.] every 6 h) and antiepileptic treatment (500 mg levatiracetam I.V. every 12 h). She improved neurologically and received in-patient rehabilitation. She developed no further complications or additional neurological deficits. However, her cognitive impairment, residual dysphagia, and neurogenic bladder were still present. She was referred to a nursery clinic for ongoing rehabilitation. She died of aspiration pneumonia and sepsis 3 months after the last surgery.
|Figure 2: Intra-parenchymal hemorrhages in right parietal lobe and bilateral cerebellum accompanied with pneumocephalus and subarachnoid hemorrhage|
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| Discussion|| |
Over-drainage of cerebrospinal fluid (CSF) resulting in remote cerebellar hemorrhage (RCH) has been well-documented in the literature. , RCH is associated with cranial and less with spinal surgeries (100 vs. 15 cases in the literature). ,,,,, However, concomitant supra- and infra-tentorial intra-parenchymal hemorrhage after spine surgery is very rare; only 7 cases were reported in the literature [Table 1]. ,,,,,, Female:male ratio is 6:2 and the median age is 52.5 years (range = 28-69 years) for patients with concomitant supra- and infra-tentorial intra-parenchymal hemorrhage after spine surgery. These patients underwent spinal surgery for spondylopathic myelopathy, spinal canal stenosis, intervertebral disc herniation, failed back surgery, chordoma, and intradural extramedullary spinal tumor. Signs and symptoms for the intra-parenchymal hemorrhage were headache, nausea, seizure, hemiparesia, delayed arousal from anesthesia, impaired consciousness, dysarthria, dysphasia, lethargy, hypotonia, dysmetria, adiodochokinesia, and dilated nonreactive pupils. These signs and symptoms developed within seconds to 2 days after the spine surgery. None of the surgical levels was more risky than another.
|Table 1: Concomitant supra-and infra-tentorial intra-parenchymal hemorrhages after spine surgery in the literature|
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One of the theories for intracranial hemorrhage after CSF leakage in spine surgery suggests that intra-luminal pressure in vessels increases and ruptures the vessels.  Subdural hematoma develops, when large venous sinuses rupture.  The second theory suggests that the inferior displacement of cerebellum causes the entrapment of venous sinuses between the cerebellum and skull base. Therefore, the venous infarction of the brain parenchyma occurs. , The third theory is associated with the second one. However, the third one suggests that massive loss of CSF causes acute occlusion of the intracranial bridging veins. , In a postmortem case study, Cornips et al. demonstrated many occluded small veins.  Massive loss of CSF has been considered a risk factor for more devastating intracranial hemorrhage. 
In 8 patients with concomitant supra- and infra-tentorial hemorrhage after spine surgeries, 2 patients underwent spinal dural repair and 6 patients were treated nonsurgically (in one case, family refused any further surgery). ,,,,,, Two patients died of brain herniation and 1 patient died of aspiration pneumonia and sepsis. , Four patients totally recovered and 1 patient partially recovered with residual findings. ,,,,
| Conclusion|| |
Symptoms including constant headache, nausea, vomiting, impaired consciousness, new onset seizure and focal neurological deficit after spine surgeries should raise the suspicion of intracranial intra-parenchymal hemorrhage. Intracranial intra-parenchymal hemorrhage should be evaluated neuro-radiologically to determine the severity and to treat patient surgically or nonsurgically in a timely manner.
Financial support and sponsorship
Murat Şakir Ekşi, M.D. was supported by a grant from Tubitak (The Scientific and Technological Research Council of Turkey), Grant number: 1059B191400255.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Toczek MT, Morrell MJ, Silverberg GA, Lowe GM. Cerebellar hemorrhage complicating temporal lobectomy. Report of four cases. J Neurosurg 1996;85:718-22.
Andrews RT, Koci TM. Cerebellar herniation and infarction as a complication of an occult postoperative lumbar dural defect. AJNR Am J Neuroradiol 1995;16:1312-5.
Konya D, Ozgen S, Pamir MN. Cerebellar hemorrhage after spinal surgery: Case report and review of the literature. Eur Spine J 2006;15:95-9.
Chadduck WM. Cerebellar hemorrhage complicating cervical laminectomy. Neurosurgery 1981;9:185-9.
Mikawa Y, Watanabe R, Hino Y, Ishii R, Hirano K. Cerebellar hemorrhage complicating cervical durotomy and revision C1-C2 fusion. Spine (Phila Pa 1976) 1994;19:1169-71.
Satake K, Matsuyama Y, Iwata H, Sato K, Kawakami N. Cerebellar haemorrhage complicating resection of a cervical intramedullary tumour. Spinal Cord 2000;38:504.
Morandi X, Riffaud L, Carsin-Nicol B, Guegan Y. Intracerebral hemorrhage complicating cervical "hourglass" schwannoma removal. Case report. J Neurosurg 2001;94(1 Suppl):150-3.
Thomas G, Jayaram H, Cudlip S, Powell M. Supratentorial and infratentorial intraparenchymal hemorrhage secondary to intracranial CSF hypotension following spinal surgery. Spine (Phila Pa 1976) 2002;27:E410-2.
Bowers CA, Taussky P, Duhon BS, Schmidt MH. Multiple supra- and infratentorial intraparenchymal hemorrhages presenting with seizure after massive sacral cerebrospinal fluid drainage. Spine (Phila Pa 1976) 2011; 36:E288-91.
Takahashi Y, Nishida K, Ogawa K, Yasuhara T, Kumamoto S, Niimura T, et al.
Multiple intracranial hemorrhages after cervical spinal surgery. Neurol Med Chir (Tokyo) 2012;52:643-5.
You SH, Son KR, Lee NJ, Suh JK. Remote cerebral and cerebellar hemorrhage after massive cerebrospinal fluid leakage. J Korean Neurosurg Soc 2012; 51:240-3.
Leung GK, Chan JP. Supratentorial Intraparenchymal Haemorrhages during Spine Surgery. J Korean Neurosurg Soc 2014;55:103-5.
Cornips EM, Staals J, Stavast A, Rijkers K, van Oostenbrugge RJ. Fatal cerebral and cerebellar hemorrhagic infarction after thoracoscopic microdiscectomy. Case report. J Neurosurg Spine 2007;6:276-9.
Amini A, Osborn AG, McCall TD, Couldwell WT. Remote cerebellar hemorrhage. AJNR Am J Neuroradiol 2006;27:387-90.
Farag E, Abdou A, Riad I, Borsellino SR, Schubert A. Cerebellar hemorrhage caused by cerebrospinal fluid leak after spine surgery. Anesth Analg 2005; 100:545-6.
Morofuji Y, Tsunoda K, Takeshita T, Hayashi K, Kitagawa N, Suyama K, et al.
Remote cerebellar hemorrhage following thoracic spinal surgery. Neurol Med Chir (Tokyo) 2009;49:117-9.
Park JS, Hwang JH, Park J, Hamm IS, Park YM. Remote cerebellar hemorrhage complicated after supratentorial surgery: Retrospective study with review of articles. J Korean Neurosurg Soc 2009;46:136-43.
Nowak R, Maliszewski M, Krawczyk L. Intracranial subdural hematoma and pneumocephalus after spinal instrumentation of myelodysplastic scoliosis. J Pediatr Orthop B 2011;20:41-5.
Friedman JA, Ecker RD, Piepgras DG, Duke DA. Cerebellar hemorrhage after spinal surgery: Report of two cases and literature review. Neurosurgery 2002;50:1361-3.
[Figure 1], [Figure 2]