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Journal of Craniovertebral Junction and Spine
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LETTER TO EDITOR
Year : 2018  |  Volume : 9  |  Issue : 4  |  Page : 286  

Giant cell glioblastoma with spinal and spinal leptomeningeal metastasis in a child: A rare presentation of a rare tumor


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Web Publication21-Jan-2019

Correspondence Address:
Dr. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcvjs.JCVJS_97_18

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How to cite this article:
Al-Mendalawi MD. Giant cell glioblastoma with spinal and spinal leptomeningeal metastasis in a child: A rare presentation of a rare tumor. J Craniovert Jun Spine 2018;9:286

How to cite this URL:
Al-Mendalawi MD. Giant cell glioblastoma with spinal and spinal leptomeningeal metastasis in a child: A rare presentation of a rare tumor. J Craniovert Jun Spine [serial online] 2018 [cited 2019 Sep 15];9:286. Available from: http://www.jcvjs.com/text.asp?2018/9/4/286/250491



Sir,

Biswas et al. nicely described a case of giant cell glioblastoma (GCG) with spinal and spinal leptomeningeal metastasis in a 7-year-old Indian child.[1] In the light of the rarity of that neoplasm and its rare distal metastasis, I presume that the authors should consider impaired immune status in the studied child. Among conditions associated with impaired immunity, human immunodeficiency virus (HIV) infection is paramount. My presumption is based on the following point. It is worthy to mention that children with perinatal exposure to HIV are at increased risk to various neoplasms compared to nonexposed counterparts.[2] To the best of my knowledge, HIV infection is a significant health threat in India. Although no recent data are yet present on the pediatric HIV seroprevalence, the available data pointed out to the substantial HIV seroprevalence rate of 1.03% among pregnant in India.[3] Regrettably, the HIV status of the mother of the studied child was not defined. I presume that some sort of vertical HIV transmission ought to be taken into consideration in the studied child. Therefore, planning for the diagnostic panel of blood CD4 lymphocyte count and viral overload estimations was solicited in the studied child. If that panel was achieved and it disclosed HIV reactivity, the case in question could be truly regarded a novel case report. This is because HIV-associated pediatric GCG with spinal and leptomeningeal metastasis has never been reported in the pediatric literature to date. Unfortunately, the studied child succumbed before considering HIV testing.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Biswas R, Gupta S, Haresh KP, Halder A, Rath GK. Giant cell glioblastoma with spinal and spinal leptomeningeal metastasis in a child: A rare presentation of a rare tumor. J Craniovertebr Junction Spine 2018;9:202-4.  Back to cited text no. 1
    
2.
Kest H, Brogly S, McSherry G, Dashefsky B, Oleske J, Seage GR 3rd, et al. Malignancy in perinatally human immunodeficiency virus-infected children in the United States. Pediatr Infect Dis J 2005;24:237-42.  Back to cited text no. 2
    
3.
Sibia P, Mohi MK, Kumar A. Seroprevalence of human immunodeficiency virus among antenatal women in one of the institute of Northern India. J Clin Diagn Res 2016;10:QC08-9.  Back to cited text no. 3
    




 

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