Home | About JCVJS | Editorial board | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Journal of Craniovertebral Junction and Spine
Search Articles   
    
Advanced search   
 


 
   Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 4  |  Page : 300-309  

Anterior cervical osteophytes causing dysphagia: Choice of the approach and surgical problems


Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, School of Medicine, University “Federico II”, Naples, Italy

Date of Submission15-Sep-2020
Date of Acceptance15-Oct-2020
Date of Web Publication26-Nov-2020

Correspondence Address:
Giuseppe Teodonno
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, School of Medicine, University “Federico II”, Via Pansini, 5-80131 Napoli
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcvjs.JCVJS_147_20

Rights and Permissions
   Abstract 


Background: Anterior cervical osteophytes (ACOs) may rarely cause dysphagia, dysphonia, and dyspnea. Symptomatic ACOs are most commonly located between C3 and C7, whereas those at higher cervical (C1–C2) levels are rarer. We report a case series of 4 patients and discuss the best surgical approach according to the ostheophyte location and size, mainly for those located at C1–C2, and the related surgical problems.
Materials and Methods: Four patients (two males and two females) aged from 57 to 72 years were operated on for ACOs, causing variable dysphagia (and dyspnea with respiratory arrest in one). Three patients with osteophytes between C3 and C5 were approached through antero-lateral cervical approach, and one with a large osteophyte between C1 and C3–C4 level underwent a two-stage transcervical and transoral approach. All had significant postoperative improvement of dysphagia.
Results: The patient operated on though the transoral approach experienced postoperative flogosis of the prevertebral tissues and occipital muscles and thrombosis of the right jugular vein and transverse-sigmoid sinuses (Lemierre syndrome).
Conclusion: The transoral approach is the best surgical route to resect C1 and C2 ACOs, whereas the endoscopic endonasal approach is not indicated. The anterior transcervical approach is easier to resect osteophytes at C3, as well as those located below C3. A combined transoral and anterior cervical approach may be necessary for multilevel osteophytes.

Keywords: Anterior cervical osteophytes, cranio-vertebral junction, dysphagia, transcervical approach, transoral approach


How to cite this article:
Maiuri F, Cavallo LM, Corvino S, Teodonno G, Mariniello G. Anterior cervical osteophytes causing dysphagia: Choice of the approach and surgical problems. J Craniovert Jun Spine 2020;11:300-9

How to cite this URL:
Maiuri F, Cavallo LM, Corvino S, Teodonno G, Mariniello G. Anterior cervical osteophytes causing dysphagia: Choice of the approach and surgical problems. J Craniovert Jun Spine [serial online] 2020 [cited 2021 Jan 20];11:300-9. Available from: https://www.jcvjs.com/text.asp?2020/11/4/300/301624




   Introduction Top


Anterior cervical osteophytes (ACOs) are common radiological findings of the elderly, with an incidence of 20%–30% in over 60 years old patients.[1] They are usually small and asymptomatic or associated with a specific neck pain. However, when they reach a large size, they may cause dysphagia, globus sensation, and more rarely dysphonia and dyspnea.[2],[3],[4] The incidence of dysphagia in patients with ACOs is variable according to the patient's age (1% at all ages [5] and 10.6% of patients 60 years old or older observed for dysphagia evaluation [4]).

Symptomatic ACOs causing dysphagia are more commonly found at the C4–C7 levels and rarely at higher cervical levels [3],[6] (with only 7 out of 68 patients showing the involvement of C1 in a case series [6]).

The surgical approach and resection of symptomatic ACOs mainly depend on their location in height and size.

This study reports four surgical cases of ACOs, causing dysphagia and discusses the surgical problems and the best approach according to the osteophyte location.


   Materials and Methods Top


Four patients who complained of dysphagia due to ACOs, operated on in our neurosurgical unit, were reviewed retrospectively. None of them had a history of trauma, neurological and rheumatologic diseases, previous surgery, or infection.

All four patients were studied by computerized tomography (CT) of the cervical spine and barium swallow study and three also by the magnetic resonance of the cervical spine [Figure 1], [Figure 2], [Figure 3]. In all four cases, these studies excluded other causes of dysphagia.
Figure 1: Case 1: (a and b) Barium swallow study in anteroposterior (a) and lateral (b) views: Interruption of the column of contrast at the level of the osteophyte. (c and d) CT scan, axial section at C4 (c) and C5 (d): Large anterior osteophyte

Click here to view
Figure 2: Case 2: CT scan in sagittal (a) and axial (b) views: Anterior cervical osteophyte at C4–C5 level

Click here to view
Figure 3: Diagnostic studies of case 4. (a and b) Barium swallow study in lateral (a) and antero-posterior (b) views: Defect of the esophageal opacization at level of the osteophyte. (c and d) Preoperative cervical CT scan, sagittal (c) and axial C1–C2 (d) views: Anterior osteophyte extending from C1 to C3-C4 level; the calcified anterior longitudinal ligament is visible. (e-g) Postoperative studies: Cervical CT scan, sagittal (e) and axial C1–C2 (f) sections; magnetic resonance, sagittal T1-W sequence (g): Good resection of the osteophyte and normal esophageal lumen

Click here to view


The case records, diagnostic studies, surgical descriptions, and postoperative clinical and radiological data were analyzed. The dysphagia was graded according to the “Functional Outcome Swallowing Scale” (FOSS) described by Salassa [7] [Table 1]. The analyzed factors were patient age and sex, grade of dysphagia, presence of other related symptoms, location and size of the osteophyte, surgical approach and resection, complications, and clinical outcome.
Table 1: Functional outcome swallowing scale

Click here to view


In all patients, the conservative treatment, including swallowing therapy, anti-inflammatory, myorelaxing, and antireflux treatment were administered for 3 months before the surgical operation, with no clinical improvement.

The follow-up ranges from 3 months to 6 years.


   Results Top


The data of the four patients are summarized in [Table 2]. The patients were 2 men and 2 women, with age ranging from 57 to 72 years (average 65 years). All four patients complained of dysphagia for solid and two also for liquid foods, with FOSS grade ranging from 2 to 4; all also had unspecific cervical pain, variable reduction of the neck movements, pharyngeal irritation, and sensation of foreign body in the throat. One patient (case 4) also had weight loss and slight occasional dyspnea. Finally, one patient complained of significant dyspnea and experienced respiratory arrest requiring an urgent tracheostomy.
Table 2: Summary of clinical and surgical data of 4 patients with anterior cervical osteophytes causing dysphagia

Click here to view


The osteophyte was located between C3 and C5 in three patients, whereas another had a large osteophyte extending between C1 and C3–C4 discal space.

The surgical approach was transcervical antero-lateral in three cases with osteophyte located between C3 and C5 (from the right side in two cases and from the left side in one, according to the greater extension of the osteophyte). An horizontal skin incision allowed to obtain sufficient longitudinal muscle opening to well expose the upper and lower margin of the osteophyte. The microsurgical resection was made by a high-speed drill up to the base of the osteophyte.

In a patient with an osteophyte extending between C1 and C3–C4 level, a combined two-stage right transcervical and transoral approach was necessary; in fact, because of the narrow mouth opening and the hypertrophic tongue, the only transoral approach was considered insufficient.

The transoral approach was made with the patient in the supine position with intubation through a prophylactic tracheostomy and with the head secured in a Mayfield fixation. A dedicated transoral system was used for the approach. The osteophyte was found to occupy the mouth cavity [Figure 4]a. A longitudinal midline incision of the posterior pharyngeal wall allowed to expose the osteophyte which was resected by drilling [Figure 4]b up to visualize the partially preserved anterior longitudinal ligament [Figure 4]c.
Figure 4: Intraoperative images of the transoral approach to C1–C2 anterior osteophyte (case 4). (a) The osteophyte is visible in the mouth cavity; the posterior pharyngeal wall is cut on the midline (↑). (b) The osteophyte is exposed. (c) The osteophyte is almost wholly resected; the partially preserved anterior longitudinal ligament is visible (↑)

Click here to view


In all four patients, the osteophyte was largely excised up to obtain a smooth spinal curve. Intraoperative X-ray studies were performed in all cases to confirm the resection. No spinal fusion was made.

No major immediate postoperative complications, such as laryngeal damage, esophageal perforation or major vascular injury, occurred. However, patient 4 operated on by combined transcervical and transoral approach experienced, 1 month after the transoral surgery, severe neck pain, and fever. Radiological studies evidenced flogosis of the paravertebral tissues and occipital muscles and thrombosis of the right jugular vein and transverse-sigmoid sinuses. This condition was diagnosed with Lemierre syndrome,[8],[9] due to infection from Streptococcus constellatus. Complete clinical remission of the infectious complication was obtained by antibiotic and anticoagulant therapy.

The clinical outcome was as follows. Dysphagia disappeared or significantly improved from 2 to 3 grades of the FOSS scale [Table 2]. In one patient, who experienced respiratory arrest, the tracheostomy was removed 2 months after the surgery and the respiratory function returned to be normal.


   Discussion Top


ACOs may sometimes become symptomatic with different mechanisms, including mechanical compression of the pharynx and esophagus, periosteophyte and pharyngo-esophageal inflammation, fibrosis, displacement of the laryngeal structures, and pharyngeal spasm.[10],[11],[12],[13] Dysphagia is the main and more frequent complaint; dyspnea, dysphonia, and hoarseness are rarer.

Patients with ACOs and dysphagia should be first treated conservatively with swallowing therapy, anti-inflammatory and myorelaxing drugs. These therapies result in long-term clinical improvement or remission in many cases.

The surgical treatment of ACOs with the aim to resolve the dysphagia was suggested for about 60 years, as confirmed by some literature reviews.[14],[15],[16] More frequent mid- or low cervical osteophytes were treated by standard anterolateral cervical approach; those located in the high cervical region, significantly less frequent, were approached through the transoral route. Besides, other endoscopic approaches, such as endonasal and cervical, should be evaluated.

Anterolateral cervical approach

The standard anterolateral cervical approach is used in most patients. We have reviewed 67 studies reported in the literature of the past 25 years, which include patients with symptomatic ACOs treated by this approach.[11],[12],[13],[17],[18],[19],[20],[21],[22],[23],[24],[25],[26],[27],[28],[29],[30],[31],[32],[33],[34],[35],[36],[37],[38],[39],[40],[41],[42],[43],[44],[45],[46],[47],[48],[49],[50],[51],[52],[53],[54],[55],[56],[57],[58],[59],[60],[61],[62],[63],[64],[65],[66],[67],[68],[69],[70],[71],[72],[73],[74],[75],[76],[77],[78],[79],[80] Nineteen studies [29],[30],[34],[38],[39],[49],[50],[51],[54],[56],[62],[63],[67],[69],[73],[76],[77],[78],[80] report series of 4 or more patients while the others are reports of one to three patients. An overall number of 198 patients have been collected.

The data of the 198 reviewed cases are summarized in [Table 3]. These show a significant prevalence of men (91% vs. 9%), mainly aged between 60 and 80 years. Most patients had involvement of one to 3 levels, mainly from C3 to C6. High C2–C3 (7%) and low C7–T2 (5%) osteophytes were rare; besides, there were no lesions extending to C1.
Table 3: Data of 198 reviewed patients with anterior cervical osteophytes treated by anterolateral transcervical approach (1995- 2020)

Click here to view


Dysphagia was the main complaint (92%); 39 patients (20%) presented variable dyspnea requiring perioperative tracheostomy in 17. Chronic neck pain (12%) and dysphonia (9%) were less frequent.

Preoperative diagnostic studies included barium swallowing study (45%), cervical spine X-ray (71.5%), CT (69.5%), and magnetic resonance (44%) of the cervical spine. An anterior spinal fusion was associated after the osteophyte resection in 35 patients (17%).

Postoperative complications included hematoma of the surgical field in 6 cases (3%) (requiring reoperation in 4), laryngeal nerve palsy in 2 (1%), complete aphagia in one, wound infection, epidural abscess, and stroke in one, respectively. No other major complications (esophageal perforation or major vessel injury) are reported.

Remission or variable improvement of dysphagia and other symptoms are reported in 96% of the patients, whereas 4% were unchanged or worsened.

Data on regrowth and recurrence are missed in most studies because of the short follow-up. Some studies report no regrowth after a median follow-up of about 2 years [62],[73] and initial regrowth at median follow-up of 53 months;[51] on the other hand, in their series of 7 cases with follow-up from 6 to 13 years Miyamoto et al.[49] report radiological recurrence in all cases with related symptoms in two. Thus, it seems that the osteophyte recurrence is not a negligible problem in the long-term follow-up, mainly in younger patients. Suggested prophylactic measures include therapy with indomethacin, additional anterior stabilization, and radiotherapy.[49],[67],[77] However, there are no precise guidelines.

We agree that all patients should be explored preoperatively by barium swallow study with the aim to confirm that the dysphagia is mechanical due to osteophytic compression. The diagnostic protocol should also include CT and magnetic resonance, to better define the osteophyte and exclude its extension into the spinal canal. On the other hand, the X-ray of the cervical spine, used as a unique diagnostic study in several reviewed otolaryngological series, is not sufficient.

The anterolateral cervical approach requires a greater longitudinal opening of the muscle planes to expose the frequent multilevel osteophytes. For strictly median osteophytes, the side of the approach may be decided according to the surgeon preference. Osteophytes with significantly asymmetric growth should be approached by the side of the greater growth to reduce the risk of damaging the esophagus displaced contralaterally. The dissection must be careful because of the adhesions of the osteophyte with the surrounding tissues and esophagus due to the lack of normal anterior longitudinal ligament. Intraoperative X-ray controls (or CT if available) are necessary to define the entity of the bone resection.

The need for fusion, performed in 35 (17.5%) of the reviewed cases, is controversial. Anterior fusion with interbody cage and/or anterior cervical plate is suggested to prevent instability and osteophyte regrowth.[49],[62] However, it requires the discectomy, the most extensive dissection of the prevertebral tissues, and longer surgical time. Thus, in agreement with most reviewed studies, we did not perform fusion in our patients.

Transoral approach

Anterior osteophytes located at C1 and C2 are better approached by the transoral route.[69],[81] This approach through the incision of the posterior pharyngeal wall in the midline, allows direct exposure to the osteophyte protruding in the mouth cavity. This is associated with low risk of damaging the main vascular structures, the vagus, and laryngeal nerves.[82]

The transoral approach to the high cervical osteophytes is reported only in five studies.[20],[24],[69],[81],[83] On the other hand, even a large series of patients treated by transoral approach to the cervical spine for different pathologies do not include cases of osteophytes or diffuse skeletal hyperostosis.[84],[85] The large study of 533 transoral operations by Choi and Crockard [86] does not focus on anterior osteophytes. Besides, in the literature review by Verlaan et al.[16] including 134 surgical cases of cervical osteophytes reported between 1980 and 2010, only one study includes a patient treated by transoral approach.[19]

The data of the 12 reviewed patients with anterior osteophytes of the high cervical region treated by transoral approach are summarized in [Table 4].[20],[24],[69],[81],[83] Differently from those located below C3, a female prevalence (8 among 12 cases) is evidenced. Dysphagia was referred to in 9 cases, odynophagia in 3, and dysphonia in 3. The transoral technique was microsurgical in 5 cases and endoscopic in 7. The postoperative complications include cervical instability in one case ad infection in another. Clinical improvement or remission occurred in all cases.
Table 4: Data of 12 reported cases of anterior cervical osteophytes treated by transoral approach

Click here to view


The intraoperative surgical problems related to the osteophyte resection by the transoral approach deserve to be discussed [Table 5].
Table 5: Surgical approaches to C1-C2 anterior cervical osteophytes

Click here to view


The transoral approach is commonly used for different pathologies, including rheumatoid arthritis, impressio basilaris, developmental anomalies C0–C2, fractures C1–C2, chordomas, and other tumors. Almost all these lesions, except for several tumors, are located within the vertebral bodies, posterior to the anterior longitudinal ligament, and do not protrude in the mouth cavity and pharynx. Thus, a rather wide working area is available. On the other hand, symptomatic ACOs are often large; they variably protrude in the mouth cavity and then occupy most of the surgical field. In this way, the working area is more limited. Although the drilling may be realized in a cranial to caudal direction, it may be difficult to control the inferior margins of the osteophyte, mainly when it extends to C3 and when the mouth opening is narrow. The tongue retraction and the palate splitting are disadvantages of this technique;[82],[87] besides, the transoral approach cannot be used in patients with mouth opening of <3 cm. The lateral exposure of the transoral approach is 15–20 mm bilaterally;[82] thus, if the osteophyte extends in the paramedian region, further lateral exposure may involve the risk of damaging the hypoglossal nerve and the vertebral artery. The intraoperative X-ray control is particularly important during the transoral approach because of the difficulty to define the depth of the resection and the lack of the surgical landmark of the anterior vertebral surface, as for the anterolateral approach.

If the bone resection is limited to the osteophyte, by sparing the anterior longitudinal ligament (if still present), the vertebral bodies and the C2–C3 disc, the posterior fusion, often advised for transoral approaches for other pathologies, is not necessary.

Although the video-assisted endoscopy may be useful to better visualize the blind angles around the osteophyte,[81],[83] we think that the microsurgical technique allows a good view in almost all cases.[88]

The C3 vertebral osteophytes may be approached by both antero-lateral transcervical and transoral routes. In our experience, the antero-lateral cervical approach allows to well expose and resect the osteophyte, thus avoiding the transoral approach. Multilevel osteophytes extending above and below C3 may be approached by a combined transoral and antero-lateral approach in one-stage or two-stage operation, as in the case of our series.

Endoscopic transcervical approach

The endoscopic transcervical approach to the craniovertebral junction, proposed by Wolinsky et al.,[89] is realized through minimally invasive tubular retractors with endoscopically controlled dissection. The advantages of this technique include the sterile surgical field, the lesser retraction with lower related complications [Table 5]. However, the working angle is narrow and the working distance is long [Figure 5]. Besides, this approach allows bone resection only in caudal to cranial direction, differently from the transoral approach, which also permits a superior to the inferior trajectory.
Figure 5: Schematic approaches to the high cervical (C1–C2) osteophytes. (a) Endoscopic endonasal approach allowing exposure to C1 and odontoid process. (b) Transoral approach allowing good exposure to C1–C2 and high half of C3. (c) Endoscopic transcervical approach from C4 to C2

Click here to view


The transcervical endoscopic approach was first described for odontoid resection. On the other hand, we did not find reported cases of anterior osteophytes treated by this technique.

Although this approach may be useful for pathologies located from C4 to the inferior clivus, its optimal surgical trajectory is for lesions at or below C2; on the other hand, this approach is not recommended for access to the inferior clivus and C1. Because the transcervical approach is performed through dissection between the spine and the pharyngeal-esophagus complex, the large anterior osteophytes hinder this dissection. Although the osteophyte may be resected by drilling in a caudal to cranial dissection, its dome and superior angle are not controlled [Table 5].

Endoscopic endonasal approach

The endoscopic endonasal approach allows to well expose the craniovertebral junction, C1 and odontoid process [90],[91] [Figure 5], as shown by several anatomic studies from our neurosurgical group.[92],[93] Some conventional radiological lines, such as the nasopalatine [94] and nasoaxial [95] lines, have defined the inferior limit of the approach at the dens or at the upper half of the C2 body. Because of its limited downward extension and the oblique surgical view, the endoscopic endonasal approach is limited to C1, whereas the exposure of C2 is rather difficult. Besides, in the presence of an anterior osteophyte, the approach requires a more downward oblique trajectory to expose the dome of the osteophyte [Table 5]. For these reasons, we did not find cases of high cervical anterior osteophyte treated by this approach. We agree that the transoral approach provides a more direct surgical view to C1-C2 anterior osteophytes than the endoscopic endonasal approach.[85],[88],[96],[97]

Although the transoral approach carries the risk of infection from the oral flora, the rate of infection of transoral surgery is low with prophylactic antibiotics, ranging from 0.6% to 4%.[86],[98],[99] A patient of our series presented pharyngeal flogosis extended to the prevertebral tissues and thrombosis of the right jugular vein and sigmoid-transverse sinuses. The inflammatory process, defined as “Lemierre's syndrome,” is observed mainly as consequence of otolaryngological and pharyngeal infections,[8],[9],[100] but it has not previously reported as a complication of transoral surgery.


   Conclusion Top


The transoral approach is the best surgical route to resect C1 and C2 ACOs; on the other hand, the endoscopic endonasal approach is not indicated. Although osteophytes located at the C3 vertebral body may also be approached by the transoral route, the anterior transcervical approach is easier, as for those located from C3 to C7. A combined transoral and anterior transcervical approach may be necessary for multilevel osteophytes.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Akbal A, Kurtaran A, Selcuk B, Gurcan A, Ersoz M, Akyuz M. The development of dysphagia and dysphonia due to anterior cervical osteophytes. Rheumatol Int 2009;29:331-4.  Back to cited text no. 1
    
2.
Gamache FW Jr., Voorhies RM. Hypertrophic cervical osteophytes causing dysphagia. A review. J Neurosurg 1980;53:338-44.  Back to cited text no. 2
    
3.
Seidler TO, Pèrez Alvarez JC, Wonneberger K, Hacki T. Dysphagia caused by ventral osteophytes of the cervical spine: clinical and radiographic findings. Eur Arch Otorhinolaryngol 2009;266:285-91.  Back to cited text no. 3
    
4.
Granville LJ, Musson N, Altman R, Silverman M. Anterior cervical osteophytes as a cause of pharyngeal stage dysphagia. J Am Geriatr Soc 1998;46:1003-7.  Back to cited text no. 4
    
5.
Strasser G, Schima W, Schober E, Pokieser P, Kaider A, Denk DM. Cervical osteophytes impinging on the pharynx: importance of size and concurrent disorders for development of aspiration. AJR Am J Roentgenol 2000;174:449-53.  Back to cited text no. 5
    
6.
Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 1976;119:559-68.  Back to cited text no. 6
    
7.
Salassa JR. A functional outcome swallowing scale for staging oropharyngeal dysphagia. Dig Dis 1999;17:230-4.  Back to cited text no. 7
    
8.
Hong P, MacCormick J, Lamothe A, Corsten M. Lemierre syndrome: Presentation of three cases. J Otolaryngol. 2005;34: 352-8.  Back to cited text no. 8
    
9.
Shimada M, Morinaga Y, Kitazaki T, Fukuda M, Hashiguchi K, Yanagihara K, et al. A severe case of lemierre syndrome with streptococcus constellatus infection. Jpn J Infect Dis 2014;67:488-9.  Back to cited text no. 9
    
10.
Mariniello G, Briganti F, De Caro MLDB, Maiuri F. Cervical extradural En-plaque meningioma. J Neurological Surgery, Part A: Central European Neurosurg 2012;73:330-3.  Back to cited text no. 10
    
11.
Di Vito J Jr. Cervical osteophytic dysphagia: Single and combined mechanisms. Dysphagia 1998;13:58-61.  Back to cited text no. 11
    
12.
Marks B, Schober E, Swoboda H. Diffuse idiopathic skeletal hyperostosis causing obstructing laryngeal edema. Eur Arch Otorhinolaryngol 1998;255:256-8.  Back to cited text no. 12
    
13.
Kos MP, van Royen BJ, David EF, Mahieu HF. Anterior cervical osteophytes resulting in severe dysphagia and aspiration: Two case reports and literature review. J Laryngol Otol. 2009;123:1169-73.  Back to cited text no. 13
    
14.
Lambert JR, Tepperman PS, Jimenez J, Newman A. Cervical spine disease and dysphagia. Four new cases and a review of the literature. Am J Gastroenterol 1981;76:35-40.  Back to cited text no. 14
    
15.
Greg Brandenberg BS, Lyal G, Leibrock MD. Dysphagia and dysphonia secondary to anterior cervical osteophytes. Neurosurgery 1986;18:90-3,  Back to cited text no. 15
    
16.
Verlaan JJ, Boswijk PF, de Ru JA, Dhert WJ, Oner FC. OnerDiffuse idiopathic skeletal hyperostosis of the cervical spine: An underestimated cause of dysphagia and airway obstruction. Spine J 2011;11:1058-67.  Back to cited text no. 16
    
17.
McCafferty RR, Harrison MJ, Tamas LB, Larkins MV. Ossification of theanterior longitudinal ligament and Forestier's disease: An analysisof seven cases. J Neurosurg 1995;83:13-7.  Back to cited text no. 17
    
18.
Valadka AB, Kubal WS, Smith MM. Updated management strategy for patients with cervical osteophytic dysphagia. Dysphagia 1995;10:167-71.  Back to cited text no. 18
    
19.
Demuynck K, van Calenbergh F, Goffin J, Verschakelen J, Demedts M, van de Woestijne K. Upper airway obstruction caused by a cervical osteophyte. Chest 1995;108:283-4.  Back to cited text no. 19
    
20.
Ramadass T, Muthubabu K, Hegde SK. Giant cervical osteophytes their significance in ENT practice. Indian J Otolaryngol Head Neck Surg 1997;49:394-8.  Back to cited text no. 20
    
21.
Riviérez M. Forestier disease disclosed by dysphagia. Apropos of a case. Neurochirurgie 1997;43:169-72.  Back to cited text no. 21
    
22.
Epstein NE, Hollingsworth R. Ossification of the cervical anterior longitudinal ligament contributing to dysphagia. Case report. J Neurosurg 1999;90:261-3.  Back to cited text no. 22
    
23.
Goel R, Sampath P, Mikaelian DO. Dysphagia caused by cervical osteophytes: three cases treated successfully by surgery. Otolaryngol Head Neck Surg 1999;120:92-6.  Back to cited text no. 23
    
24.
Motsch C, Grasshoff H, Freigang B. Anterior hyperostosis of the cervical spine: diagnostic studies and surgical therapy. Laryngorhinootologie 1999;78:150-4.  Back to cited text no. 24
    
25.
Akhtar S, O'Flynn PE, Kelly A, Valentine PM. The management of dysphagia in skeletal hyperostosis. J Laryngol Otol 2000;114:154-7.  Back to cited text no. 25
    
26.
Matan AJ, Hsu J, Fredrickson BA. Management of respiratory com-promise caused by cervical osteophytes: A case report and review ofthe literature. Spine J 2002;2:456-9.  Back to cited text no. 26
    
27.
Ido K, Hashitani M, Sakamoto A, Urushidani H. Surgical treatment for dysphagia caused by cervical hyperostosis: A report of three cases. J Orthopaed Traumatol 2002;3:55-8.  Back to cited text no. 27
    
28.
Giddings CE, Caulfield HM, Dorward NL. Diffuse idiopathic skeletal hyperostosis resulting in dysphagia and aspiration pneumonia. Br J Neurosurg 2003;17:467-8.  Back to cited text no. 28
    
29.
Fuerderer S, Eysel-Gosepath K, Schröder U, Delank KS, Eysel P. Retro-pharyngeal obstruction in association with osteophytes of the cervical spine. J Bone Joint Surg Br 2004;86:837-40.  Back to cited text no. 29
    
30.
Mizuno J, Nakagawa H, Song J. Symptomatic ossification of the anterior longitudinal ligament with stenosis of the cervical spine: A report of seven cases. J Bone Joint Surg Br 2005;87:1375-9.  Back to cited text no. 30
    
31.
Calisaneller T, Ozdemir O, Tosun E, Altinors N. Dysphagia due to diffuse idiopathic skeletal hyperostosis. Acta Neurochir (Wien) 2005;147:1203-6.  Back to cited text no. 31
    
32.
Galiano K, Gotwald T, Maier H, Schatzer R, Obwegeser AA. Rapidly progressive dysphagia caused by Forestier's disease: A case report. Wien Klin Wochenschr 2005;117:234-6.  Back to cited text no. 32
    
33.
Ng J, Gnanalingham KK, Stokes O, Singh A, Casey A. Anterior cervico-thoracic osteophytes: An unusual cause of dysphagia. Br J Neurosurg 2005;19:173-4.  Back to cited text no. 33
    
34.
Castellano DM, Sinacori JT, Karakla DW. Stridor and dysphagia in diffuse idiopathic skeletal hyperostosis (DISH). Laryngoscope2006;116:341-4.  Back to cited text no. 34
    
35.
Giger R, Dulguerov P, Payer M. Anterior cervical osteophytes causing dysphagia and dyspnea: An uncommon entity revisited. Dysphagia 2006;21:259-63.  Back to cited text no. 35
    
36.
Di Martino A, Vincenzo C, Vincenzo D. Dysphagia and dysphonia due to anterior cervical osteophytes: Report of a patient affected by DISH. Eur J Orthop Surg Traumatol 2006;16:344-7.  Back to cited text no. 36
    
37.
Montinaro A, D'Agostino A, Punzi F, Cantisani PL. Cervical anterior hyperostosis: A rare cause of dysphagia. Report of 3 cases. J Neurosurg Sci 2006;50:75-7.  Back to cited text no. 37
    
38.
Nelson RS, Urquhart AC, Faciszewski T. Diffuse idiopathic skeletal hyperostosis: A rare cause of dysphagia, airway obstruction, and dysphonia. J Am Coll Surg 2006;202:938-42.  Back to cited text no. 38
    
39.
Song J, Mizuno J, Nakagawa H. Clinical and radiological analysis of ossification of the anterior longitudinal ligament causing dysphagia and hoarseness. Neurosurgery 2006;58:913-9.  Back to cited text no. 39
    
40.
Alcazar L, Jerez P, Gomez-Angulo JC, Tamarit M, Navarro R, Ortega JM, et al. Forestier-rotes-querol's disease. Ossification of the anterior cervical longitudinal ligament as a cause of dysphagia ([in Spanish]) Neurocirugia (Astur) 2008;19:350-5.  Back to cited text no. 40
    
41.
Burduk PK, Wierzchowska M, Grzelalak L, Dalke K, Mierzwiński J. Diffuse idiopathic skeletal hyperostosis inducted stridor and dysphagia. Otolaryngol Pol 2008;62:138-40.  Back to cited text no. 41
    
42.
Caminos CB, Cenoz IZ, Louis CJ, Otano TB, Esáin BF, Pérez de Ciriza MT. Forestier disease: an unusual cause of upper airway obstruction. Am J Emerg Med 2008;26:1072.e1-3.  Back to cited text no. 42
    
43.
Constantoyannis C, Papadas T, Konstantinou D. Diffuse idiopathic skeletal hyperostosis as a cause of progressive dysphagia: A case report. Cases J 2008;1:416.  Back to cited text no. 43
    
44.
De Jesus-Monge WE, Cruz-Cuevas EI. Dysphagia and lung aspiration secondary to anterior cervical osteophytes: A case report and review of the literature. Ethn Dis 2008;18:S2-137-40.  Back to cited text no. 44
    
45.
Park E, Kang S, Rhim S, Roh SW, Jeon SR. Dysphagia caused by anterior cervical osteophytes: Different surgical outcomes in three cases. Korean J Spine 2008;5:207-10.  Back to cited text no. 45
    
46.
Solaroǧlu I, Okutan O, Karakuş M, Saygili B, Beşkonakli E. Dysphagia due to diffuse idiopathic skeletal hyperostosis of the cervical spine. Turk Neurosurg 2008;18:409-11.  Back to cited text no. 46
    
47.
Krishnarasa B, Vivekanandarajah A, Ripoll L, Chang E, Wetz R. Diffuse idiopathic skeletal hyperostosis (DISH)-a rare etiology of dysphagia. Clin Med Insights Arthritis Musculoskelet Disord 2011;4:71-5.  Back to cited text no. 47
    
48.
Lin HW, Quesnel AM, Holman AS, Curry WT Jr., Rho MB. Hypertrophic anterior cervical osteophytes causing dysphagia and airway obstruction. Ann Otol Rhinol Laryngol 2009;118:703-7.  Back to cited text no. 48
    
49.
Miyamoto K, Sugiyama S, Hosoe H, Iinuma N, Suzuki Y, Shimizu K. Postsurgical recurrence of osteophytes causing dysphagia in patients with diffuse idiopathic skeletal hyperostosis. Eur Spine J 2009;18:1652-8.  Back to cited text no. 49
    
50.
Oppenlander ME, Orringer DA, La Marca F, McGillicuddy JE, Sullivan SE, Chandler WF, et al. Dysphagia due to anterior cervical hyperosteophytosis. Surg Neurol 2009;72:266-70.  Back to cited text no. 50
    
51.
Urrutia J, Bono CM. Long-term results of surgical treatment of dysphagia secondary to cervical diffuse idiopathic skeletal hyperostosis. Spine J 2009;9:e13-7.  Back to cited text no. 51
    
52.
Goh PY, Dobson M, Iseli T, Maartens NF. MaartensForestier's disease presenting with dysphagia and dysphonia. J Clin Neurosci 2010;17:1336-8.  Back to cited text no. 52
    
53.
Lecerf P, Malard O. How to diagnose and treat symptomatic anterior cervical osteophytes? Eur Ann Otorhinolaryngol Head Neck Dis 2010;127:111-6.  Back to cited text no. 53
    
54.
Ozgursoy OB, Salassa JR, Reimer R, Wharen RE, Deen HG. Anterior cervical osteophyte dysphagia: Manofluorographic and functional outcomes after surgery. Head Neck 2010;32:588-93.  Back to cited text no. 54
    
55.
Vengust R, Mihalic R, Turel M. Two different causes of acute respiratory failure in a patient with diffuse idiopathic skeletal hyperostosis and ankylosed cervical spine. Eur Spine J 2010;19:S130-4.  Back to cited text no. 55
    
56.
Carlson ML, Archibald DJ, Graner DE, Kasperbauer JL. Surgical management of dysphagia and airway obstruction in patients with prominent ventral cervical osteophytes. Dysphagia 2011;26:34-40.  Back to cited text no. 56
    
57.
Kapetanakis S, Vasileiadis I, Papanas N, Goulimari R, Maltezos E. Can a giant cervical osteophyte cause dysphagia and airway obstruction? A case report. Wien Klin Wochenschr 2011;123:291-3.  Back to cited text no. 57
    
58.
Fox TP, Desai MK, Cavenagh T, Mew E. Diffuse idiopathic skeletal hyperostosis: A rare cause of dysphagia and dysphonia. BMJ Case Rep 2013;2013. pii: bcr2013008978.  Back to cited text no. 58
    
59.
Hwang JS, Chough CK, Joo WI. Giant anterior cervical osteophyte leading to Dysphagia. Korean J Spine 2013;10:200-2.  Back to cited text no. 59
    
60.
Seo JW, Park JW, Jang JC, Kim JW, Lee YG, Kim YT, et al. Anterior cervical osteophytes causing Dysphagia and paradoxical vocal cord motion leading to dyspnea and dysphonia. Ann Rehabil Med 2013;37:717-20.  Back to cited text no. 60
    
61.
Bacigaluppi S, Merciadri P, Secci F, Bragazzi NL, Zona G. An unusual cause of dysphagia: “DISHphagia”. Br J Neurosurg 2015;29:275-6.  Back to cited text no. 61
    
62.
von der Hoeh NH, Voelker A, Jarvers JS, Gulow J, Heyde CE. Results after the surgical treatment of anterior cervical hyperostosis causing dysphagia. Eur Spine J 2015;24 Suppl 4:S489-93.  Back to cited text no. 62
    
63.
Jeong H, Seo HG, Han TR, Chung CK, Oh BM. Kinematic changes in swallowing after surgical removal of anterior cervical osteophyte causing Dysphagia: A case series. Ann Rehabil Med 2014;38:865-70.  Back to cited text no. 63
    
64.
Zhang C, Ruan D, He Q, Wen T, Yang P. Progressive dysphagia and neck pain due to diffuse idiopathic skeletal hyperostosis of the cervical spine: A case report and literature review. Clin Interv Aging 2014;9:553-7.  Back to cited text no. 64
    
65.
Egerter AC, Kim ES, Lee DJ, Liu JJ, Cadena G, Panchal RR, et al. Dysphagia secondary to anterior osteophytes of the cervical spine. Glob Spine J 2015;5:e78-83.  Back to cited text no. 65
    
66.
Chen YR, Sung K, Tharin S. Symptomatic anterior cervical osteophyte causing dysphagia: Case report, imaging, and review of the literature. Cureus 2016;8:e473.  Back to cited text no. 66
    
67.
Vodičar M, Košak R, Vengust R. Long-term results of surgical treatment for symptomatic anterior cervical osteophytes: A case series with review of the literature. Clin Spine Surg 2016;29:E482-E487.  Back to cited text no. 67
    
68.
Allensworth JJ, O'Dell KD, Schindler JS. Bilateral vocal fold paralysis and dysphagia secondary to diffuse idiopathic skeletal hyperostosis. Head Neck 2017;39:E1-3.  Back to cited text no. 68
    
69.
Erdur O, Tasli H, Polat B, Sofiyev F, Tosun F, Çolpan B, et al. Surgical management of dysphagia due to anterior cervical osteophytes. J Craniofac Surg 2017;28:e80-4.  Back to cited text no. 69
    
70.
Karaarslan N, Gürbüz MS, Çalışkan T, Simsek AT. Forestier syndrome presenting with dysphagia: Case report of a rare presentation. J Spine Surg 2017;3:723-6.  Back to cited text no. 70
    
71.
Alsalmi S, Bugdadi A, Alkhayri A, Fichten A, Peltier J. Urgent anterior cervical osteophytectomy for an asymptomatic cervical hyperostosis to overcome failed intubation. Cureus 2018;10:e2400.  Back to cited text no. 71
    
72.
Hongo M, Miyakoshi N, Fujii M, Kasukawa Y, Ishikawa Y, Kudo D, et al. Pyogenic spondylitis caused by methicillin-resistant staphylococcus aureus associated with tracheostomy followed by resection of ossification of the anterior longitudinal ligament. Case Rep Orthop 2018;2018:5.  Back to cited text no. 72
    
73.
Lui Jonathan YC, Sayal P, Prezerakos G, Russo V, Choi D, Casey AT. The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis. Clin Neurol Neurosurg 2018;167:36-42.  Back to cited text no. 73
    
74.
Psychogios G, Jering M, Zenk J. Cervical hyperostosis leading to dyspnea, aspiration and dysphagia: Strategies to improve patient management. Front Surg 2018;5:33.  Back to cited text no. 74
    
75.
Sebaaly A, Boubez G, Sunna T, Wang Z, Alam E, Christopoulos A, et al. diffuse idiopathic hyperostosis manifesting as dysphagia and bilateral cord paralysis: A case report and literature review. World Neurosurg 2018;111:79-85.  Back to cited text no. 75
    
76.
Yoshioka K, Murakami H, Demura S, Kato S, Yonezawa N, Takahashi N, et al. Surgical treatment for cervical diffuse idiopathic skeletal hyperostosis as a cause of dysphagia. Spine Surg Relat Res 2018;2:197-201.  Back to cited text no. 76
    
77.
Ruetten S, Baraliakos X, Godolias G, Komp M. Surgical treatment of anterior cervical osteophytes causing dysphagia. J Orthop Surg (Hong Kong) 2019;27. doi: 2309499019837424.  Back to cited text no. 77
    
78.
Scholz C, Naseri Y, Hohenhaus M, Hubbe U, Klingler JH. Long-term results after surgical treatment of diffuse idiopathic skeletal hyperostosis (DISH) causing dysphagia. J Clin Neurosci 2019;67:151-5.  Back to cited text no. 78
    
79.
Soejima Y, Arima J, Doi T. Diffuse idiopathic skeletal hyperostosis: A case with dysphonia, dysphagia and myelopathy. Am J Case Rep 2019;20:349-53.  Back to cited text no. 79
    
80.
Damade C, Masse R, Ghailane S, Petit M, Castelain JE, Gille O, et al. Anterior cervical idiopathic hyperostosis and dysphagia: The impact of surgical management-study of a series of 11 cases. World Neurosurg 2020;138:e305-10.  Back to cited text no. 80
    
81.
Jabarkheel R, Chen YR, Xu L, Yan CH, Patel ZM, Desai AM. Transoral endoscopic resection of high cervical osteophytes with long-term symptom resolution: Case series, imaging, and literature review. World Neurosurg 2018;120:240-3.  Back to cited text no. 81
    
82.
Hsu W, Wolinsky JP, Gokaslan ZL, Sciubba DM. Transoral approaches to the cervical spine. Neurosurgery 2010;66:119-25.  Back to cited text no. 82
    
83.
Sanromán-Álvarez P, González-Vargas P, Rodríguez-Fernández JL, De la Lama-Zaragoza A. Fully endoscopic transoral resection of high cervical osteophyte. How I do it? Acta Neurochir (Wien) 2020;162:131-4.  Back to cited text no. 83
    
84.
Perrini P, Benedetto N, Guidi E, Di Lorenzo N. Transoral approach and its superior extensions to the craniovertebral junction malformations: Surgical strategies and results. Neurosurgery 2009;64:331-42.  Back to cited text no. 84
    
85.
Visocchi M, Signorelli F, Liao C, Rigante M, Ciappetta P, Barbagallo G, et al. Transoral versus transnasal approach for craniovertebral junction pathologies: Which route is better? Acta Neurochir Suppl 2019;125:181-6.  Back to cited text no. 85
    
86.
Choi D, Crockard HA. Evolution of transoral surgery: Three decades of change in patients, pathologies, and indications. Neurosurgery 2013;73:296-303.  Back to cited text no. 86
    
87.
Baird CJ, Conway JE, Sciubba DM, Prevedello DM, Quiñones-Hinojosa A, Kassam AB. Radiographic and anatomic basis of endoscopic anterior craniocervical decompression: A comparison of endonasal, transoral, and transcervical approaches. Neurosurgery 2009;65:158-63.  Back to cited text no. 87
    
88.
Pillai P, Baig MN, Karas CS, Ammirati M. Endoscopic image-guided transoral approach to the craniovertebral junction: an anatomic study comparing surgical exposure and surgical freedom obtained with the endoscope and the operating microscope. Neurosurgery 2009;64:437-42.  Back to cited text no. 88
    
89.
Wolinsky JP, Sciubba DM, Suk I, Gokaslan ZL. Endoscopic image-guided odontoidectomy for decompression of basilar invagination via a standard anterior cervical approach. Technical note. J Neurosurg Spine 2007;6:184-91.  Back to cited text no. 89
    
90.
Kassam AB, Snyderman C, Gardner P, Carrau R, Spiro R. The expanded endonasal approach: A fully endoscopic transnasal approach and resection of the odontoid process: technical case report. Neurosurgery 2005;57:E213.  Back to cited text no. 90
    
91.
Visocchi M, Signorelli F, Liao C, Rigante M, Paludetti G, Barbagallo G, et al. Endoscopic endonasal approach for craniovertebral junction pathologic conditions: Myth and truth in clinical series and personal experience. World Neurosurg 2017;101:122-9.  Back to cited text no. 91
    
92.
Cavallo LM, Cappabianca P, Messina A, Esposito F, Stella L, de Divitiis E, et al. The extended endoscopic endonasal approach to the clivus and cranio-vertebral junction: Anatomical study. Childs Nerv Syst 2007;23:665-71.  Back to cited text no. 92
    
93.
Messina A, Bruno MC, Decq P, Coste A, Cavallo LM, de Divittis E, et al. Pure endoscopic endonasal odontoidectomy: anatomical study. Neurosurg Rev 2007;30:189-94.  Back to cited text no. 93
    
94.
de Almeida JR, Zanation AM, Snyderman CH, Carrau RL, Prevedello DM, Gardner PA, et al. Defining the nasopalatine line: The limit for endonasal surgery of the spine. Laryngoscope 2009;119:239-44.  Back to cited text no. 94
    
95.
Aldana PR, Naseri I, La Corte E. The naso-axial line: A new method of accurately predicting the inferior limit of the endoscopic endonasal approach to the craniovertebral junction. Neurosurgery 2012;71:ons308-14.  Back to cited text no. 95
    
96.
Seker A, Inoue K, Osawa S, Akakin A, Kilic T, Rhoton AL Jr. Comparison of endoscopic transnasal and transoral approaches to the craniovertebral junction. World Neurosurg 2010;74:583-602.  Back to cited text no. 96
    
97.
Visocchi M, Germano' A, Umana G, Richiello A, Raudino G, Eldella AM, et al. Direct and oblique approaches to the craniovertebral junction: Nuances of microsurgical and endoscope-assisted techniques along with a review of the literature. Acta Neurochir Suppl 2017;124:107-16.  Back to cited text no. 97
    
98.
Shousha M, Mosafer A, Boehm H. Infection rate after transoral approach for the upper cervical spine. Spine (Phila Pa 1976) 2014;39:1578-83.  Back to cited text no. 98
    
99.
Yin Q, Xia H, Wu Z, Ma X, Ai F, Zhang K, et al. Surgical site infections following the transoral approach: A review of 172 consecutive cases. Clin Spine Surg 2016;29:E502-8.  Back to cited text no. 99
    
100.
Johannesen KM, Bodtger U. Lemierre's syndrome: Current perspectives on diagnosis and management. Infect Drug Resist 2016;9:221-7.  Back to cited text no. 100
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

Top
  
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
    Materials and Me...
   Results
   Discussion
   Conclusion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed378    
    Printed14    
    Emailed0    
    PDF Downloaded9    
    Comments [Add]    

Recommend this journal