Home | About JCVJS | Editorial board | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Journal of Craniovertebral Junction and Spine
Search Articles   
Advanced search   

   Table of Contents  
Year : 2022  |  Volume : 13  |  Issue : 2  |  Page : 212-220  

Alternative approach to treatment of unusual site giant cell tumor at cervical spine: A case report and review of literature

1 Department of Neurosurgery; Shiraz Neuroscience Research Center, Shiraz University of Medical Science, Shiraz, Iran
2 Hematology Research Center, Shiraz University of Medical Science, Shiraz, Iran
3 Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran
4 Trauma Research Center; Department of Pathology, Molecular Pathology and Cytogenetics Division, Shiraz University of Medical Science, Shiraz, Iran

Date of Submission25-Mar-2022
Date of Acceptance14-Apr-2022
Date of Web Publication13-Jun-2022

Correspondence Address:
Majidreza Farrokhi
Department of Neurosurgery, Chamran Hospital, Shiraz
Sanaz Taherpour
Department of Neurosurgery, Chamran Hospital, Shiraz
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcvjs.jcvjs_45_22

Rights and Permissions

Giant cell tumor (GCT) is an intermediate malignant bone tumor which mostly involves long extremity bones, less commonly involving the spine with sacral predominance. Cervical spine involvement is rare. According to literature, the selective approach for the treatment of GCT is en bloc resection with spinal reconstruction. For unusual sites, such as cervical region, which is a mobile spinal segment and critically proximate to the cervical spinal cord, great vessels, and vital organs, it is almost impossible to perform the selective approach for treatment. Alternative approaches in such situations are under investigations. We present a case of C2 vertebral body GCT, who was treated with polymethylmethacrylate intravertebral injection and was followed by adjuvant therapy with denosumab. A 16-year-old boy without any past medical history presented with progressive suboccipital and axial neck pain since 3 months earlier, which had not responded to conservative treatments. There was no neurologic deficit, and pain was significantly controlled. In the 1-year follow-up, no complication and tumor recurrence was seen. Vertebroplasty with bone cement for lytic spinal GCT lesions, followed by adjuvant therapy with denosumab, not only is a less invasive treatment but also has good results in spinal stability, patient recovery, and 12-month recurrence.

Keywords: Cervical spine, denosumab, giant cell tumor, vertebroplasty

How to cite this article:
Mousavi SR, Rezvani A, Eghbal K, Motlagh MA, Dehghanian AR, Taherpour S, Farrokhi M. Alternative approach to treatment of unusual site giant cell tumor at cervical spine: A case report and review of literature. J Craniovert Jun Spine 2022;13:212-20

How to cite this URL:
Mousavi SR, Rezvani A, Eghbal K, Motlagh MA, Dehghanian AR, Taherpour S, Farrokhi M. Alternative approach to treatment of unusual site giant cell tumor at cervical spine: A case report and review of literature. J Craniovert Jun Spine [serial online] 2022 [cited 2023 Jun 2];13:212-20. Available from: https://www.jcvjs.com/text.asp?2022/13/2/212/347326

   Introduction Top

Natural history

Giant cell tumor (GCT) is a biologically unpredictable primary bone tumor.[1] According to the WHO 2020 classification, GCT is an intermediate malignant bone tumor with invasion capability to surrounding tissue.[2] It accounts for 5% of all primary bone tumors, mostly involving the appendicular skeleton, of which only 2%–4% occur in the spine.[1] Sacral bone is the most common site of involvement in the spine, while cervical region is the least.[3] In another study, spinal GCTs were reported as common as 2.7%–6.5%.[4] GCT has a female predominance with average presenting age of 20–40 years.[5]


The most common presenting symptoms are pain and limited range of motion. Neural involvement is also frequent and seen in more than 70% of cases.[4]


The prognosis of GCTs in the mobile spine is worse, in comparison to extremities, due to higher fragility and proximity to the neural elements.[1]


Histologically, GCTs are known as osteoclastoma and are characterized by a hypercellular field consisting of multinucleated giant cells among a population of mononucleated, oval, or round cells.[1] In previous literature, GCTs have been considered benign. This may provide a wrong concept regarding the behavior and progression of these tumors because their osteolytic nature may cause severe damage to surrounding tissues. There are also a 13.5% chance of lung metastasis and a 2% chance of sarcomatous transformation in malignant cases.[1]

Diagnostic methods

Findings of computerized tomography (CT) scan (an expansile osteolytic lesion with cortical insufflation) and magnetic resonance imaging (MRI) (T1 isointense and T2 iso- to hyperintense with peripheral enhancement with gadolinium) are not pathognomonic for the diagnosis of GCTs, so histopathologic investigations on tissue biopsy samples are necessary for definite diagnosis.[4] “H3F3A” mutation is a known specific marker of GCTs and may be a diagnostic confirmation tool for these tumors.[5]

Differential diagnoses

Aneurysmal bone cyst (ABC), simple bone cyst, chondroblastoma, osteoid osteoma, osteoblastoma, osteosarcoma, giant cell reparative granuloma, and brown tumor of hyperparathyroidism are the main differential diagnoses of GCTs.[4]


To date, there has been no confirmed algorithm to treat spinal GCTs, which may be due to a lack of clinical trials and comparative studies on such tumors, which, in turn, can be attributable to the rarity of the cases.[1] However, the standard treatment for spinal GCTs, especially in the case of neural involvement, is, so far, surgical procedures including en bloc resection, intralesional resection, curettage, or intraoperative adjuvant therapies – such as vertebroplasty or cryotherapy.[4] For recurrence or tumor remnants after surgical resection, radiotherapy, selective embolization, cryotherapy, vertebroplasty, argon plasma coagulation, bisphosphonates, interferon-alpha-2-b, and denosumab are among adjuvant therapies.[4]

As to the pertinent literature, Tsukamoto et al.[2] provided a treatment algorithm for malignant and nonmalignant GCTs in a review study conducted on a collection of previous studies.


Spondylectomy for en bloc resection provides the best long-term prognosis and disease-free survival.[1] Intralesional surgical resection has 72.2% disease-free survival.[1] As GCTs are radiosensitive tumors, adjuvant radiotherapy has been reported to bring about 60%–80% long-term disease control. On the other hand, megavoltage radiotherapy has a great risk of malignant transformation.[1] Despite the already mentioned measures, tumor recurrence has been reported 26%–50% in literature.[4]

In general, several treatment approaches have been utilized with different outcomes[5] that will be discussed in relevant parts of this study. Thus, large-scale prospective studies are required to provide an acceptable treatment algorithm for GCTs.[5]

   Case Report Top

Clinical presentation

A 16-year-old boy without any past medical history presented with progressive suboccipital and axial neck pain since 3 months earlier, which had not responded to conservative treatments. Radiologic investigation revealed a mass in C2 vertebral body and dense process. In MRI examination, the lesion turned out to be a cystic mass in C2 vertebral body, iso-intense in T1 and iso-hyper-intense in T2 with enhancement in gadolinium study [Figure 1]. CT scan also revealed an expansile osteolytic lesion with cortical insufflation [Figure 2]. Following the preliminary diagnosis, due to the unusual site of tumor, the patient was referred to the spine surgery subspecialty center for further investigations and treatment.
Figure 1: MRI of the cervical spine, showing a well-identified C2 lesion with odontoid process involvement without extension to extradural space. A cystic lesion of the C2 vertebral body that has isointense signal in T1 (a), iso- to hyperintense signal in T2 (b), and enhanced with gadolinium study (c and d). MRI: Magnetic resonance imaging

Click here to view
Figure 2: Preoperation cervical spine Computed tomography scan examination, showing an expansile osteolytic lesion with cortical insufflation of C2 vertebral body, involving odontoid process. Axial, coronal, and sagittal views of C2 vertebra from left to right, respectively. CT: Computerized tomography. axial (a), coronal (b), sagittal (c)

Click here to view

In neurologic examination, all muscle powers were intact; no sensory level, sphincter problem, or gate disturbance was detected, and no sign of myelopathy was found. Furthermore, there was not any noticeable problem in family history or social background.

Based on the published literature, open surgical resection methods and radiotherapy were not possible for our case due to unusual location and adjacent vital neurovascular tissues. Besides, due to high probability of local recurrence and, thus, devastating complications, adjuvant therapy was highly indicated for this patient. Furthermore, CT-guided biopsy was not feasible for this patient in our interventional radiology department. Therefore, our planning seminar – consisting spine surgeon, interventional radiologist, pathologist, and oncologist – agreed with open curettage biopsy and pathologic investigation on frozen sections. Vertebroplasty and adjuvant therapy with denosumab were decided and followed for our patient after pathologic confirmation.

Operative procedure

Following the complete spinal imaging, C2 was confirmed as the only site of involvement, and, thus, the patient was prepared for surgery. Having described the intervention mode, its potential complications, and other possible treatment approaches, informed consent was obtained from both the patient and his parents. As the initial step, under general anesthesia, the patient was situated in proper supine position. After preparing and draping the surgical field, through retropharyngeal approach, C2 vertebral body was exposed under fluoroscopic guidance, and needle biopsy was performed. The sample was sent for frozen sectioning and immediate pathologic investigation, which proved to be GCT. Further pathologic examinations also confirmed the diagnosis [Figure 3]. Using polymethylmethacrylate (PMMA), vertebroplasty was performed for C2 vertebral body and odontoid process. The surgery was completed with no problematic event [Figure 4].
Figure 3: Histopathological evaluation of the lesion. (a and b) Histopathological sections show sheets of tumoral stromal cells admixed with evenly distributed numerous giant cells. Stromal cells show vesicular oval nuclei with conspicuous nucleoli (H and E, ×40, ×100) (c) Giant cells (arrowhead) show numerous nuclei which are morphologically identical to the stromal cells (H and E, ×400)

Click here to view
Figure 4: Early postoperation (C2 vertebroplasty) CT scan examination of the cervical spine. Axial, coronal, sagittal, and Scott views from left to right, respectively. CT: Computerized tomography. axial (a,b), coronal (c), sagittal (d)

Click here to view

Postoperative course

After proper recovery, the patient was transferred to the ward with rigid cervical collar and was discharged after tolerating mobilization and oral feeding, having significant limiting pain, and without any neurologic deficit. In his 2-week follow-up, adjuvant therapy with subcutaneous injection of 120 mg denosumab every 28 days was started for him. The patient underwent follow-up for pain control, clinical examination, and CT scan investigation every 3 months for local tumor recurrence investigation. After 12 months, there was no tumor recurrence and no neurologic deficit and pain was significantly controlled. In 6-month postoperative CT scan follow-up, areas of new bone formation were detectable around injected bone cement [Figure 5].
Figure 5: Follow_up CT scan examination of the cervical spine after 12 months. Areas of new bone formation were detectable around injected bone cement. Axial, coronal, sagittal, and Scott views from left to right, respectively. CT: Computerized tomography. axial (a), coronal (b), sagittal (c), scott view (d)

Click here to view

We obtained informed consent from the patient and his parents for the publication of this study.

   Discussion Top

The low prevalence of spinal GCTs has limited performing extensive clinical trials and comparative studies to obtain an acceptable treatment algorithm for such tumors.[1] Furthermore, to date, standard treatment for GCT has been surgical resection, yet in cases of tumor recurrence, remnants, or inoperable situations, adjuvant therapies have been successfully applied.[6] Case reports about alternative treatment approaches to spinal GCTs are briefly reviewed [Table 1].
Table 1: Alternative treatment approach to spine giant cell tumors

Click here to view

Surgical approaches

En bloc resection and spondylectomy

Spondylectomy to obtain en bloc surgical resection, as the main treatment for GCTs, has provided the best long-term prognosis and disease-free survival. On the other hand, en bloc surgical resection is not possible for many spinal GCTs due to proximity to the spinal cord and neurovascular structures.[5],[11] Preoperative embolization before en bloc surgical resection facilitates surgery and significantly decreases the intraoperative hemorrhage.[21] Retrospective observational studies show that 35.1% of patients who went under en bloc surgical resection have experienced at least one complication.[1] This approach, in conjunction with spinal fixation and reconstruction, is available for the lower lumbar region and is curative for GCTs.[1] For multilevel lesions in the lumbosacral junction, this approach is more challenging and complicated, requiring a multidisciplinary teamwork process. Besides, prior to the surgery, the patient and his/her family should be well informed regarding major morbidities.[1] A case of T11 GCT with associated scoliosis was presented in 2017, treated with preoperative denosumab for 8 weeks and then en bloc surgical resection under CT scan navigation. This study showed a beneficial effect of denosumab and CT navigation on facilitating and easing en bloc surgical resection.[15]

Intralesional tumor resection

Intralesional surgical resection, providing 72.2% disease-free survival, is an alternative surgical treatment when en bloc surgical resection is not possible.[1] For instance, intralesional surgical resection following arterial embolization is the best option in cases where there is a high probability of neural damage through en bloc surgical resection, such as sacral GCTs.[22] Besides intraoperative hemorrhage control, preoperative arterial embolization helps extending surgical resection and thus decreases the risk of local recurrence and, therefore, better outcomes are achieved.[23] If utilizing denosumab as neoadjuvant therapy, curettage of tumor margins together with intralesional resection shows a lower local recurrence rate.[24] Whether denosumab can ease the intralesional resection and help preserving important structures such as joints and neurovascular structures is still under question.[24] High rate of local recurrence in GCTs is a challenging and concerning issue. The minimum time duration for the recurrence is predicted as 10 years following the last surgery. To prevent the local recurrence, applying proper treatment strategy and assessing risk factors are crucial per se. In such regard, intralesional surgical resection has proved beneficial in local recurrence control.[25]

Minimal invasive approaches


GCT potential for malignancy has caused the treatment approach in spinal forms for complete resection of tumor to be extensive, mostly requiring two-step surgeries – dorsal and ventral. Literature reveals that intralesional curettage and bone cement injection have led to solid fixation. This approach was performed for the first time in 1998 for a case of thoracic spine GCT, leading to significant solid fixation.[26] In another case report of sacral GCT in 2008, 4 mg of zoledronate was administered every 4 weeks following intralesional curettage plus bone cement injection. Within a 2-year follow-up, the patient did not report any disturbing pain, neurologic deficit, or local tumor recurrence.[10] In a retrospective study of 4 sacral GCT cases in 2015, zoledronic acid-loaded bone cement following intralesional curettage was recommended for better local tumor control.[27] For spinal tumors, bone cement injection reduces resistant pains through the mechanisms of mechanical bone stability, destruction of irritated nerve endings, and induction of tumor necrosis.[10] Paul in 2006 proved complete GCT tumor necrosis after vertebroplasty on the basis of radiographic and histologic findings and assumed tumor necrosis to be due to the cytotoxic effect of PMMA and thermal tissue injury of PMMA polymerization process.[20] Therefore, vertebroplasty can be regarded as an appropriate alternative treatment when spondylectomy is not feasible.[10] In 2013, a case of sacroiliac GCT underwent anterior-posterior wide tumor resection followed by bone cement injection for spinal reconstruction. According to this experience, bone cement can be taken as an effective alternative and a less invasive reconstructive method rather than complicated expensive fixators and allografts.[28]

Serial embolization

Based on the previous studies, therapeutic embolization without surgical intervention or adjuvant radiotherapy has been effective in treating sacral GCTs in an 8-year follow-up. On the other hand, 10 years of follow-up has shown 31% tumor recurrence for patients who underwent embolization as the only treatment.[1] When used as neoadjuvant therapy before surgical resection of sacral GCT, embolization can reduce the intraoperative bleeding and yield better optimal resection.[2],[23] In patients who are at higher risk of surgical complications after en bloc resection, intralesional resection following arterial embolization is the best option with good local tumor control.[22],[23] In a case series in 2012, serial arterial embolization was reported as an effective alternative treatment in inoperable cases for not only sacral GCTs but also other spinal areas.[21] In addition, Cebula et al., in the same year, reported a case of hypervascular C2 GCT surrounded by ABC, for whom arterial embolization was performed 3 times with ONYX followed by complete tumor resection. Spinal reconstruction was done using C2 vertebral body and odontoid cementoplasty plus anterior C3-prosthesis plate.[18]


Müller et al., in 2016, suggested that in patients for whom curettage and adjuvant therapy with denosumab are utilized, better results for local tumor control will be gained by more aggressive curettage plus intralesional phenol, hydrogen peroxide, or liquid nitrogen injection. They also stated that they would prefer cryotherapy with liquid nitrogen.[29]

Nonsurgical Approaches

Treatment with denosumab

Denosumab is a human monoclonal antibody, acting in bone remodeling by bounding to stimulatory receptor: nuclear factor-β ligand receptor activator of nuclear factor kappa-B ligand (RANKL). It was first approved for osteoporosis treatment. Afterward, in 2013, it also received the Food and Drug Administration (FDA) approval for bone metastases and bone tumors including GCT. In the same year, it was successfully used as neoadjuvant therapy for patients with long bone GCTs who could not undergo surgical total resection due to high risk of complications and such severe morbidities as amputation or joint loss. It acts through osteoclast inactivation and, thus, reduces bone resorption.[3],[6] According to histological research, GCTs' stroma consists of giant oval osteoclasts, which highly present stimulation receptor for nuclear factor- ligand. This characteristic represents the osteoclastic nature of these tumors, and denosumab, as a monoclonal antibody against this receptor, can be an effective alternative treatment option for GCTs.[27] For extremity GCTs, denosumab is administered for 2 loading doses of 120 mg on days 8 and 15, then after 4 weeks, 120 mg every 4 weeks for 6 months.[3] According to histologic investigations in 2010, denosumab is capable of significantly reducing GCT tumor cells and arresting radiologic tumor progression.[1] Controlling pain (reduction in Visual Analog Score), alleviating surgical resection and curettage, improving functional outcome, reducing intraoperative hemorrhage, and changing the course of disease to latent form are other noticeable effects of this drug. However, due to higher recurrence in patients who were administered with only neoadjuvant therapy with denosumab, adjuvant therapy was also suggested for better local tumor control.[2],[6],[29] Besides, there is evidence that adding denosumab to GCT curettage improves the outcome and reduces recurrence. It is even better to perform more aggressive curettage and use phenol, hydrogen peroxide, or liquid nitrogen in the site for more local tumor control.[29] In their literature review in 2018, Agarwal et al. warned about routine utilization of denosumab in GCT treatment. They stated that using denosumab as neoadjuvant therapy prior to intralesional resection or curettage not only does not improve local tumor recurrence but also raises it. Thus, the questions remain whether or not neoadjuvant therapy facilitates surgical resection and what its proper dose, duration of use, and the best indications could be.[24],[14] As recommended, adjuvant denosumab administration is better be kept for patients with a high risk of tumor recurrence, extensive local tumor invasion, close approximation to neurovascular structures, and evidences of lung metastasis. As a result, physicians are highly recommended to take into account the pros and cons of denosumab and consider the warning signs before administering it for GCT treatment.[14] After FDA approval for denosumab administration in GCT patients, an international multicenter clinical trial of its use was started in 2013. The target population were spinal GCT patients (including sacral GCTs), whose disease was in its active phase based on clinical and radiologic evidence. The patients were categorized into three groups, namely surgical unsalvageable giant cell tumors of bone (GCTBs), patient's candidate for surgery but with a high risk of postoperative morbidity, and others who were added from previous studies.[30] The standard treatment for GCT is surgical resection or curettage with intraoperative adjuvant therapy. However, some patients were not good candidates for surgery due to their unusual site of tumor. The results of this study were published in 2020, in which denosumab administration dose was suggested as 120 mg every 4 weeks with 2 loading doses on days 8 and 15. Denosumab was shown to have a beneficial role in spinal GCTs (including sacral GCTs).[30] It is noticeable that more than half of patients with resectable spinal GCTs (including sacral GCTs) benefit a good level of disease control and decide to proceed with denosumab rather than surgical treatment. Randomization could not be done in this study due to low prevalence of the disease.[30] This research, after all, is in favor of using denosumab as an alternative treatment for patients with unresectable GCTs. The safety profile in the subgroup of patients for spinal GCTs (including sacral) was consistent with total population, and no new safety signals were detected.[30]

As to the side effects, there has been no report of jaw necrosis or hypocalcemia in drug complication studies. There were some reports of periapical abscess and periodontal disease in the course of treatment with denosumab, suggesting oral and dental examination before starting the treatment with denosumab. Renal function tests and serum calcium level investigation before starting the treatment and daily Vitamin D (more than 400 IU) and calcium (more than 500 mg) supplement administration during treatment have also been advised.[6]

Although for locally invasive tumors and those resistant to medical treatments, surgical intervention is crucial, it is reasonable to consider nonsurgical treatments for craniovertebral junction and atlantoaxial tumors (benign or malignant) in the first place due to their complex anatomy. It should also be considered that resection of lytic lesions in these areas can lead to spinal instability and alter atlantoaxial angles, endangering nearby neurovascular structures. Therefore, surgical resection depends on spinal fusion and stabilization.[9] Keeping all the aforementioned lines in mind, after considering warnings and specific conditions, denosumab can be applied as adjuvant or neoadjuvant therapy in spinal GCTs (especially the cervical region).

Denosumab (120 mg/month for 2 years) was administered in 2016 for a case of cervical GCT, which was unresectable due to the unusual site and proximity to neurovascular structures. Tumor necrosis and regression showed up in CT scan after a 6-month follow-up, and no tumor recurrence occurred after a follow-up of 2 years.[13]

The first case of successful disease control with denosumab was presented in 2018, who was a 53-year-old patient with cervical GCT, undergoing surgical resection with positive surgical margins. In this patient, the disease remained stable even after reducing the dose of the drug, so it was returned to the previous dose. Hence, denosumab is a good treatment option in cases of unresectable tumors and high risk for severe postoperative morbidity. The ideal dose and duration for GCT treatment and whether or not it causes complete or partial GCT remission is still unknown and requires further research.[17]

In cases of inoperable spinal GCTs and candidates for en bloc resection, neoadjuvant therapy with denosumab is preferred,[2],[15] and in cases of lung metastasis, “wait-and-see” approach is primarily taken, and treatment with denosumab is suggested for growing tumors.[2]


GCT is a radiosensitive tumor; thus, radiotherapy can provide 60%–84% long-term local tumor control.[2] For spinal GCT, 100% treatment response and 98% overall survival are reported in a literature review.[2] However, due to high risk of malignant transformation (33%), radiotherapy is not suggested, especially for young patients. Local tumor recurrence 2 years after radiotherapy is considered malignancy.[2],[17] Therefore, it should be kept for instances where surgical intervention is impossible and other alternative options, such as zoledronate, denosumab, and embolization, are not available.[2]

Carbon-ion beam therapy

According to a case report in 2021, in a case of surgically resected cervical GCT with autologous bone graft, local tumor recurrence was recognized following a 4-month follow-up. The patient underwent carbon-ion beam therapy with a 70.4 Gy dose in 32 sessions for 7 weeks, and after 5 years of follow-up, there was no sign of neurologic deficit, disease recurrence, or malignant transformation.[31]


Chemotherapy is not generally suggested as a standard treatment option for spinal GCT.[1]

   Conclusion Top

Spinal GCT, as a tumor with a high probability of local recurrence and invasion, requires a proper treatment plan to control local recurrence and prevent nearby neurovascular structure damage. The gold standard treatment for this tumor is complete en bloc surgical resection. However, in the spine, especially in the cervical region, it is almost impossible due to special anatomic features. Although different alternative treatments have been utilized in this type of tumors, a unified acceptable treatment algorithm has not been given yet because the rarity of spinal GCTs prevents performing large clinical trials and conducting comparative studies. According to our experience, bone cement injection for vertebroplasty in lytic GCT lesions followed by adjuvant therapy with denosumab improves the patient recovery and spinal stability through a less invasive procedure besides no recurrence after 12-month follow-up.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Santiago-Dieppa DR, Hwang LS, Bydon A, Gokaslan ZL, McCarthy EF, Witham TF. L4 and L5 spondylectomy for en bloc resection of giant cell tumor and review of the literature. Evid Based Spine Care J 2014;5:151-7.  Back to cited text no. 1
Tsukamoto S, Mavrogenis AF, Kido A, Errani C. Current concepts in the treatment of giant cell tumors of bone. Cancers (Basel) 2021;13:3647.  Back to cited text no. 2
Yayan J. Denosumab for effective tumor size reduction in patients with giant cell tumors of the bone: A systematic review and meta-analysis. Cancer Control 2020;27:1-7.  Back to cited text no. 3
Maldonado-Romero LV, Sifuentes-Giraldo WA, Martínez-Rodrigo MA, de la Puente-Bujidos C. Giant cell tumor of the spine: A rare cause of cervical pain. Reumatol Clin 2017;13:58-9.  Back to cited text no. 4
Al-Shamary E, Al-Dhafeeri W, Al-Sharydah A, Al-Suhibani S, Kussaibi H, Al-Issawi W. Total spondylectomy for upper thoracic spine giant cell tumor: A case report. Case Rep Oncol 2019;12:131-8.  Back to cited text no. 5
Chen X, Li H, Zhu S, Wang Y, Qian W. Pre-operative denosumab is associated with higher risk of local recurrence in giant cell tumor of bone: A systematic review and meta-analysis. BMC Musculoskelet Disord 2020;21:256.  Back to cited text no. 6
Kinoshita H, Orita S, Yonemoto T, Ishii T, Iwata S, Kamoda H, et al. Successful total en bloc spondylectomy of the L3 vertebra with a paravertebral giant cell tumor following preoperative treatment with denosumab: A case report. J Med Case Rep 2019;13:116.  Back to cited text no. 7
Afsoun S, Saied SA, Amir N, Hamed J. En-bloc resection of a giant cell tumor causing cervical vertebral collapse. Asian J Neurosurg 2018;13:150-3.  Back to cited text no. 8
[PUBMED]  [Full text]  
Heinrich C, Gospodarev V, Kheradpour A, Zuppan C, Douglas CC, Minasian T. Benign giant cell lesion of C1 lateral mass: A case report and literature review. Brain Sci 2019;9:105.  Back to cited text no. 9
Arpornchayanon O, Leerapun T. Effectiveness of intravenous bisphosphonate in treatment of giant cell tumor: A case report and review of the literature. J Med Assoc Thai 2008;91:1609-12.  Back to cited text no. 10
Lee CG, Kim SH, Kim DM, Kim SW. Giant cell tumor of upper thoracic spine. J Korean Neurosurg Soc 2014;55:167-9.  Back to cited text no. 11
Wong MN, Nicol K, Murakami JW. Image-guided percutaneous management of skull and spine giant cell tumors: Case report of 2 challenging cases successfully treated with doxycycline sclerotherapy. World Neurosurg X 2020;5:100061  Back to cited text no. 12
Nakazawa T, Inoue G, Imura T, Miyagi M, Saito W, Namba T, et al. Remarkable regression of a giant cell tumor of the cervical spine treated conservatively with denosumab: A case report. Int J Surg Case Rep 2016;24:22-5.  Back to cited text no. 13
Tsukamoto S, Tanaka Y, Mavrogenis AF, Kido A, Kawaguchi M, Errani C. Is treatment with denosumab associated with local recurrence in patients with giant cell tumor of bone treated with curettage? A systematic review. Clin Orthop Relat Res 2020;478:1076-85.  Back to cited text no. 14
Inoue G, Imura T, Miyagi M, Saito W, Tazawa R, Nakazawa T, et al. Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncol Lett 2017;14:4005-10.  Back to cited text no. 15
Sertbaş İ, Karatay M, Hacisalihoğlu UP. Cervical spine giant cell bone tumor: A case report. World J Surg Oncol 2019;17:82.  Back to cited text no. 16
Law GW, Yeo NE, Howe TS, Tan YZ, Tan SB, Siddiqui MM. Recommencement of denosumab for unresectable giant cell tumor of the cervical spine: A case report. Spine (Phila Pa 1976) 2018;43:E551-6.  Back to cited text no. 17
Cebula H, Boujan F, Beaujeux R, Boyer P, Froelich S. Giant cell tumor of the C2 colonized by an aneurismal bone cyst. Report of case. Neurochirurgie 2012;58:376-81.  Back to cited text no. 18
Panzica M, Lüke U, Omar M, Länger F, Falck CV, Krettek C. New therapy approaches for giant cell tumors. Unfallchirurg 2014;117:883-91.  Back to cited text no. 19
Paúl L, Santonja C, Izquierdo E. Complete necrosis of a spinal giant cell tumor after vertebroplasty. J Vasc Interv Radiol 2006;17:727-31.  Back to cited text no. 20
Balke M, Henrichs MP, Gosheger G, Ahrens H, Streitbuerger A, Koehler M, et al. Giant cell tumors of the axial skeleton. Sarcoma 2012;2012:410973.  Back to cited text no. 21
Martin C, McCarthy EF. Giant cell tumor of the sacrum and spine: Series of 23 cases and a review of the literature. Iowa Orthop J 2010;30:69-75.  Back to cited text no. 22
Zhou M, Yang H, Chen K, Wang G, Lu J, Ji Y, et al. Surgical treatment of giant cell tumors of the sacrum and spine combined with pre-operative transarterial embolization. Oncol Lett 2013;6:185-90.  Back to cited text no. 23
Agarwal MG, Gundavda MK, Gupta R, Reddy R. Does denosumab change the giant cell tumor treatment strategy? Lessons learned from early experience. Clin Orthop Relat Res 2018;476:1773-82.  Back to cited text no. 24
Patil S, Shah KC, Bhojraj SY, Nene AM. Recurrent spinal giant cell tumors: A study of risk factors and recurrence patterns. Asian Spine J 2016;10:129-35.  Back to cited text no. 25
Weisskopf M, Hoffmann R, Lehmann TN, Melcher I. Dorsal removal and stabilization of giant cell tumor of the thoracic spine. Unfallchirurg 1998;101:238-41.  Back to cited text no. 26
Chen KH, Wu PK, Chen CF, Chen WM. Zoledronic acid-loaded bone cement as a local adjuvant therapy for giant cell tumor of the sacrum after intralesional curettage. Eur Spine J 2015;24:2182-8.  Back to cited text no. 27
Liu HC, Lo CW, Chou TJ, Lin CN. Excision of high sacral giant cell tumor and reconstruction with bone cement. Formos J Musculoskelet Disord 2013;4:84-7.  Back to cited text no. 28
Müller DA, Beltrami G, Scoccianti G, Campanacci DA, Franchi A, Capanna R. Risks and benefits of combining denosumab and surgery in giant cell tumor of bone – A case series. World J Surg Oncol 2016;14:281.  Back to cited text no. 29
Bukata SV, Blay JY, Rutkowski P, Skubitz K, Henshaw R, Seeger L, et al. Denosumab treatment for giant cell tumor of the spine including the sacrum. Spine (Phila Pa 1976) 2021;46:277-84.  Back to cited text no. 30
Sakuda T, Furuta T, Okimoto T, Adachi N. Giant cell tumor of the cervical spine treated by carbon ion radiotherapy: A case report. Medicine (Baltimore) 2021;100:e27393.  Back to cited text no. 31


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]

  [Table 1]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
   Case Report
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded144    
    Comments [Add]    

Recommend this journal