Journal of Craniovertebral Junction and Spine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 11  |  Issue : 3  |  Page : 210--216

Survival in patients with surgically treated spinal metastases


Erion Junior de Andrade1, Cleiton Formentin1, Samilly Conceição Maia Martins2, Fernando Luis Maeda1, Otávio Turolo1, Victor Leal de Vasconcelos1, Enrico Ghizoni1, Helder Tedeschi1, Andrei Fernandes Joaquim1 
1 Department of Neurology, State University of Campinas (UNICAMP), Campinas, SP, Brazil
2 Department of Orthopedics, State University of Campinas (UNICAMP), Campinas, SP, Brazil

Correspondence Address:
Erion Junior de Andrade
R. Tessalia Vieira de Camargo, 126, Cidade Universitária, Campinas, SP
Brazil

Background: Despite the various treatment protocols available, survival evaluation is a fundamental criterion for the definition of surgical management; there are still many inconsistencies in the literature on this topic, especially in terms of the value of surgery and its morbidity in patients with very short survival. Objective: The objective was to analyze the association of clinical, oncological, and surgical factors in the survival of patients undergoing spinal surgery for spinal metastases (SM). Materials and Methods: A retrospective cohort of forty patients who were surgically treated at our institution for SM between 2010 and 2018 were included in the study. We applied the prognostic scales of Tomita and Tokuhashi in each patient and evaluated the systemic status using Karnofsky Performance Scale (KPS) and Eastern Cooperative Oncology Group Performance Scale. Survival rate in months was estimated using the Kaplan–Meier curve, with death considered as primary outcome and, for the evaluation of the association between the variables, the Chi-square test, Fisher's exact test, or Fisher–Freeman–Halton test was applied for better survival. The level of statistical significance was considered as 5% (P ≤≤ 0.05). Results: The mean survival was 8.4 months. Patients with KPS <70 had a mean survival of 6.36 months, while those with KPS >70 had a mean survival of 14.48 months (P = 0.04). The mean survival of patients classified as ECOG 2 was 7.05 months (95% confidence interval [CI]: 3.4–10.7), and that of patients classified as ECOG 3 and 4 was 1.24 months (95% CI: 0.8–1.59). The mean survival rate among the patients with unresectable metastases in other organs was 6.3 months (95% CI: 3.9–8.9), while the survival rate of those who did not have metastases was 13.8 months (95% CI: 10.0–17.68; P = 0.022). Conclusion: Survival was associated with the preoperative functional status defined by the KPS and ECOG scales and with the presence of nonresectable visceral metastases.


How to cite this article:
de Andrade EJ, Formentin C, Martins SC, Maeda FL, Turolo O, de Vasconcelos VL, Ghizoni E, Tedeschi H, Joaquim AF. Survival in patients with surgically treated spinal metastases.J Craniovert Jun Spine 2020;11:210-216


How to cite this URL:
de Andrade EJ, Formentin C, Martins SC, Maeda FL, Turolo O, de Vasconcelos VL, Ghizoni E, Tedeschi H, Joaquim AF. Survival in patients with surgically treated spinal metastases. J Craniovert Jun Spine [serial online] 2020 [cited 2020 Oct 22 ];11:210-216
Available from: https://www.jcvjs.com/article.asp?issn=0974-8237;year=2020;volume=11;issue=3;spage=210;epage=216;aulast=de;type=0